ADVOCATE. CONNECT. INNOVATE.

Fellows

Evince Biosciences, Inc.

Organization Address
Cornerstone Corporate Center
1902 Wright Place, 2nd Floor
Carlsbad, CA 92008

Website
www.evincebio.com

Industry
Biotech and Pharmaceutical

Sector
Drug Discovery and Development

Organization Description
AVO (Autonomous Virtual Organism) employs contemporary computational techniques and machine learning to modernize drug discovery. The platform accurately predicts activity against the target of interest, selectivity and drug-like properties (ADME) simultaneously, determining characteristics such as the ability to get into the bloodstream, cross the blood brain barrier and off target toxicity. AVO transforms discovery into a parallel process in a virtual environment, rather than a sequential process in a laboratory environment. AVO also enables optimization of lead compounds by using the algorithm to evaluate proposed chemical changes to a molecule. The Company’s first program targets toll-like receptor 7 (TLR7) for cancer immunotherapy. The value of a TLR7 agonist is in how it complements checkpoint inhibitors, the most important mechanism in cancer immunotherapy, but a mechanism that currently suffers from a low response rate. TLR7 agonists stimulate the innate immune system, which can improve the response rate to checkpoint inhibitors to significantly improve cancer immunotherapy and the overall treatment of cancer. This program is in late lead optimization.