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Intabio

Organization Address
1230 Bordeaux Drive
Sunnyvale, CA 94089

Organization Phone
4158064472

Website
intabio.com

Organization Description
Intabio is developing a proprietary microfluidic platform that will provide real-time, rapid, and direct characterization of intact protein isoforms in a simple and easy to use system. The development and manufacturing of biologics requires high levels of monitoring and testing due to the fact that antibody and recombinant protein drugs are produced in living cells that often introduce unintended structural modifications that can affect efficacy and toxicity. Current testing systems are cumbersome and do not provide the throughput and real-time protein analytics that today’s rapidly growing biopharma industry desperately needs. Constrained by time and resources, and faced with thousands of samples requiring analysis, samples are cherry-picked or pooled for characterization. This strategy leads to incomplete knowledge of the product quality, and potential costly missteps and delays during development. Intabio was founded to address this critical issue in protein analytics and our solution is based on a decade’s worth of deep customer insight. We are developing the Blaze system (bench-top instrument, microfluidic chip, reagent kit) to address the acute pain in biologic product development and manufacturing by providing real-time, rapid, and direct characterization of intact protein isoforms in a simple and easy to use system. Blaze uses a proprietary microfluidic platform to separate and quantitate protein isoforms based on charge heterogeneity, and if an unknown protein peak is identified, Blaze can directly interface with a mass spectrometer (MS) to identify the specific modification. Our proprietary technology provides the unique integration of three analytical techniques for separation, quantitation, and molecular mass identity that are widely used today across development, regulatory approval, and commercial manufacturing to provide characterization of protein quantity, identity, and purity.