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SyntheX

Organization Address
479 Jessie St.
San Francisco, CA 94103

Organization Phone
(415) 706-8701

Website
www.synthexlabs.com

Industry
Bioscience

Organization Description
SyntheX is a therapeutics company that disrupts cellular communication pathways to target proteins that are inaccessible via canonical screening technologies. We use a proprietary drug design approach and our in-vivo screening platform, ToRPPIDO, to identify compounds that disrupt protein-protein interactions (PPIs) - in a fast, efficient, and highly specific manner. We take advantage of synthetic lethality to develop compounds that target particular “Achilles’ heel” PPI in specific pathologies. We are currently developing inhibitors for a series of specific and previously undruggable targets. Our lead stabilized peptide inhibitor drugs, STX101 and STX105, block PPIs within the BRCA2 pathway, effectively mimicking a BRCA2 mutation and downregulating recombination.

Therapeutic Areas
Cancer; Genetic Diseases

Clinical Development Stage
PreClinical